Development of inhibitors for potential drug targets - human ADP ribosyltransferases

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Auditorium F101 of the Faculty of Biochemistry and Molecular Medicine (Aapistie 7), Zoom link: https://oulu.zoom.us/j/68257495343?pwd=eDBOMlg2dkNwbW5IMXZJTFN5b01Bdz09

Topic of the dissertation

Development of inhibitors for potential drug targets - human ADP ribosyltransferases

Doctoral candidate

Master of Science Sudarshan Narasimha Murthy

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, Protein and Structural Biology Research Unit

Subject of study

Biochemistry and Molecular Medicine

Opponent

Adj. Professor Tiina Salminen, Åbo Akademy University

Custos

Professor Lari Lehtiö, University of Oulu

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Development of inhibitors for potential drug targets - human ADP ribosyltransferases

This study focuses on the development of small-molecule inhibitors towards two ADP ribosyltransferases, ARTD10 and ARTD7. Human ADP-ribosyltransferases are enzymes which are involved in several cellular processes and are potential targets for drug development. To verify the roles of the enzymes, a high-quality inhibitor, inhibiting the enzymes specifically, is needed.

The dissertation used biochemical and structural biological methods to investigate the binding of various small molecules to ARTD enzymes. Based on this, a new inhibitor was developed for ARTD10 with better potency than previous inhibitors. The developed inhibitor can now be used as a research tool to study the function of ARTD10 in cells.

The dissertation also laid the foundation for the selective inhibition of the ARTD7 enzyme, which will be useful for future studies to help determine the effect of enzyme activity on, for example, various cancer cells.
Last updated: 14.9.2020