Discovery on somatic-germline interplay implicating prostate cancer predisposition and progression

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Auditorium F101 of the Faculty of Biochemistry and Molecular Medicine (Aapistie 7B). Remote access: https://oulu.zoom.us/s/67225616630

Topic of the dissertation

Discovery on somatic-germline interplay implicating prostate cancer predisposition and progression

Doctoral candidate

Master of Science Nikolaos Giannareas

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, FBMM

Subject of study

Prostate cancer, molecular biology genomics

Opponent

Adj.prof Leena Latonen, University of Eastern Finland

Custos

Proffesor Aki Manninen, University of Oulu

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Description of the interaction between two transcription factors and their effect on prostate cancer progression.

We identified the relationship of possible SNPs that correlate with HNF1B expression. HNF1B expression is elevated when somatic mutation of ERG (TMPRSS2-ERG) takes place in prostate cancer . HNF1B and TMPRSS2-ERG interact together and co-occupy binding sites in locus of FAM57A which can elevate its expression and progress prostate cancer.
Last updated: 2.12.2021