Kidney Ontogenesis: Roles of Fgf8 signalling and Hematopoietic Progenitor Cells

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Remote access: https://oulu.zoom.us/j/3431035651

Topic of the dissertation

Kidney Ontogenesis: Roles of Fgf8 signalling and Hematopoietic Progenitor Cells

Doctoral candidate

MSc Abhishek Sharma

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, Disease Networks

Subject of study

Developmental Biology

Opponent

PhD Odyssé Michos, Illumina, Inc.

Custos

Professor Seppo Vainio, Faculty of Biochemsitry and Molecular Medicine

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Role of Fgf8 gene in kidney development

A developing organ requires interactions between different cell types, which may lead to cell proliferation, cell differentiation, or cell migration. These processes are controlled by signalling molecules. In this work, role of a signalling factor (Fgf8) was studied in embryonic kidney development. Fgf8 is required by progenitor cells of the kidney to form a condensate around the epithelial structure which will form part of the filtration unit of the kidney (called nephron). The deletion of Fgf8 leads to smaller kidneys with immature nephron and causes death postnatally in mice. Also, in this work, the role of immune cells in embryonic kidney development was investigated. Immune cells do not play critical role in embryonic kidney development.
Last updated: 29.5.2020