Regulation of transcription factor USF2 in cancer by phosphorylation

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Faculty of Biochemistry and Molecular Medicine, hall F101 Aapistie 7, Zoom link: https://oulu.zoom.us/j/64783814748 C

Topic of the dissertation

Regulation of transcription factor USF2 in cancer by phosphorylation

Doctoral candidate

Master of Science Franklin Chi

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, ECM and Hypoxia

Subject of study

Biochemistry and Molecular Medicine

Opponent

Professor Gerhard P. Püschel, University of Potsdam

Custos

Professor Thomas Kietzmann, University of Oulu

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Regulation of transcription factor USF2 in cancer by phosphorylation

In multicellular organisms, the processes of growth, development and function are a result of gene expression. For expression, genes must be turned on and/or off in a coordinated manner in response to diverse stimuli. The coordination of the expression of a group of genes falling into the same functional category is commonly performed by transcription factor(s). These are proteins that bind specific DNA sequences in promoter or enhancer/silencer regions and regulate the transcription into mRNA.

This process of gene regulation is essential for life. In this study, we investigated mechanisms by which the function of the transcription factor USF2 can be regulated in noncancerous and cancer cells as well as the effect of USF2 loss-of-function on the cell fate.

This study provides key results explaining how USF2 can be regulated by phosphorylation and expand our knowledge on how GSK3 and CDK5 affect cell function via USF2 transactivity, DNA binding and protein stability as well as the growth of noncancerous cells by compromising mitochondria.
Last updated: 5.10.2020