Substrate specificity and substrate channeling properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme complex (MtTFE)

Thesis event information

Date and time of the thesis defence

Place of the thesis defence

Leena Palotie Hall (Aapistie 5A)

Topic of the dissertation

Substrate specificity and substrate channeling properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme complex (MtTFE)

Doctoral candidate

Master of Engineering, Biotechnology Subhadra Dalwani

Faculty and unit

University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, Protein and Structurral Biology

Subject of study

Structural Enzymology

Opponent

Professor Richard Charles Garratt, ​University of São Paulo

Custos

Docent Rajaram Venkatesan, University of Oulu

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Study to better understand the workings of an enzyme from Mycobacterium tuberculosis (Mtb) which helps Mtb survive during infection by breaking down fats obtained from its host

Mycobacterium tuberculosis (Mtb) are bacteria that cause the disease tuberculosis in humans. This disease primarily effects the lungs but can also spread to other parts of the body. There are various stages of infection where the bacteria are exposed to different environments and nutrients inside the cells of human host. Fats derived from the host have been shown to be important during certain stages of infection and are important for the survival of the bacteria. Here we have tried to understand how one of the enzymes from Mtb, which helps break down these fats, namely the trifunctional enzyme (TFE), works. We have conducted experiments that show that the Mtb TFE has a preference for certain types of fats and we propose a hypothesis on how this enzyme works.
Last updated: 11.3.2022